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250105m FIRST SERIES OF STUDENT RESEARCH GROUP MEETINGS: GROUP #13 7.00-7.55pm 09/01/2025

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Agenda of Meeting with PNU Students prepared by  Prof Omar Hasan Kasule MB ChB (MUK), MPH (Harvard), DrPH (Harvard). 

 

Time

Sunday

Jan 5, 2025

Monday

Jan 6, 2025

Tuesday

Jan 7, 2025

Wednesday

Jan 8, 2025

Thursday

Jan 9, 2025

7.00pm –

 7.55pm

 

Group 1

Group 4

Group 7

Group 10

Group 13

8.00pm –

 8.55pm

 

Group 2

Group 5

Group 8

Group 11

 

9.00pm –

 9.55pm

 

Group 3

Group 6

Group 9

Group 12

 

 

AGENDA

  • Know one another: self-introductions – 5 minutes
  • The way forward – 5 minutes
  • Presentation of the proposed research program -5 minutes
  • Q&A and open discussion – 30 minutes

 

WAY FORWARD

  • Vision: publish at least 2 papers; the first a review within 6 months and the second based on laboratory or data analysis within 1-3 years.
  • First step: We shall start by brainstorming about the assigned topic, then the group will review the literature to narrow down the topic and develop keywords
  • Second step: Systematic literature review within the group and a 1-hour presentation to Prof Omar once a week or once every two weeks.
  • Third step: familiarization with available laboratory equipment and procedures to prepare one or more research proposals from each group. Faculty will be appointed as supervisors or principal investigators. Students will be co-authors.
  • Some of the research will be new and innovative. Some of it will be attempts at validating research carried out outside the Kingdom.

 

RESEARCH PROGRAM TO ANALYZE THE WEQAYA DATA BASE FOR LONG-TERM IMMUNITY PROFILES FOLLOWING COVID AND INFLUENZA INFECTION / VACCINATION-1

  • A lot of data on vaccination and the resulting community was collected during the COVID-19 epidemic. More data is being collected on other respiratory and non-respiratory diseases
  • Data can be sourced from many channels, one being the open data platformThe Open Data Platform, which allows the publication of data collected from various government agencies in a unified portal, makes this data available to beneficiaries
  • Data can also be sourced from Weqaya databases.
  • The analysis will focus on changes in immune status after vaccination: strength and duration. This will lead to policy recommendations.

 

RESEARCH PROGRAM TO ANALYZE THE WEQAYA DATA BASE FOR LONG-TERM IMMUNITY PROFILES FOLLOWING COVID AND INFLUENZA INFECTION / VACCINATION-2

  • Examination of the data available will lead to the formulation of various hypotheses regarding immunity following vaccination.
  • The most important vaccinations to study are the COVID-19 and influenza vaccines, but others may also be explored
  • The analysis will be a longitudinal follow-up of the evolution of various antibodies following vaccination to assess long-term immunity.

 

INITIAL REFERENCES

  1. Alhandod TA, Rabbani SI, Almuqbil M, Alshehri S, Hussain SA, Alomar NF, Mir MA, Asdaq SMB. A Systematic Review on the Safety and Efficacy of COVID-19 Vaccines Approved in Saudi Arabia. Vaccines (Basel). 2023 Jan 28;11(2):281.
  2. Jain VK, Iyengar KP, Ish P. Elucidating causes of COVID-19 infection and related deaths after vaccination..Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102212.
  3. Hakjun Hyun Eliel Nham Hye Seong Jin Gu Yoon Ji Yun NohHee Jin CheongWoo Joo Kim Sun Kyung YoonSe-Jin ParkWonSeok GwakJune-Woo LeeByoungguk KimJoon Young Song . Long-term humoral and cellular immunity against vaccine strains and Omicron subvariants (BQ.1.1, BN.1, XBB.1, and EG.5) after bivalent COVID-19 vaccination. Front Immunol. 2024 May 2:15:1385135.
  4. Kreuzberger N, Hirsch C, Andreas M, Böhm L, Bröckelmann PJ, Di Cristanziano V, Golinski M, Hausinger RI, Mellinghoff S, Lange B, Lischetzki T, Kappler V, Mikolajewska A, Monsef I, Park YS, Piechotta V, Schmaderer C, Stegemann M, Vanshylla K, Weber F, Weibel S, Stephani C, Skoetz N. Immunity after COVID-19 vaccination in people with higher risk of compromised immune status: a scoping review. Cochrane Database Syst Rev. 2022 Aug 9;8(8):CD015021. 
  5. Raslan MA, Raslan SA, Shehata EM, Mahmoud AS, Sabri NA, Alzahrani KJ, Alzahrani FM, Alshammeri S, Azevedo V, Lundstrom K, Barh D. COVID-19 Vaccination in Pediatrics: Was It Valuable and Successful? .Vaccines (Basel). 2023 Jan 18;11(2):214.
  6. Uversky VN, Redwan EM, Makis W, Rubio-Casillas A IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. .Vaccines (Basel). 2023 May 17;11(5):991.