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131224L - COMPLIANCE WITH TREATMENT

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Lecture for 4th year medical students by Professor Omar Hasan Kasule


Learning objectives
·         Explore factors of compliance
·         Key words: chronic disease, treatment compliance

ISSUES TO CONSIDER
·         Autonomy: Coercion
·         Confidentiality: monitoring
·         Compliance: barriers, enhancers, coping strategies

CASE SCENARIO 1:
·         The primary care physician refused to see a chronic bronchitis patient he had been advising to cut down on smoking.
·         The patient came to the clinic smoking. The doctor told him to go away saying he will not waste his time on a disobedient patient.

CASE SCENARIO 2:
·         A 55-year old hypertensive patient on treatment refused to take any more medication because it caused him erectile dysfunction.
·         The doctor explained to him that he risked getting a stroke and suggested providing him with Viagra at the hospital’s expense.

CASE SCENARIO 3:
·         A primary care physician insists that the patient he considers incompliant should come to the clinic every morning to take his pills while the doctor is watching

CASE SCENARIO 4:
·         A surgeon who suspects the patient does not carry out scheduled exercises at home asks the patient to use his handphone to send live images of exercising to the clinic

CASE SCENARIO 5a:
·         Nathan is a healthy man in his early 40s. He works out regularly and does not smoke.
·         Dr. Wechsler is speaking to Nathan in his office regarding the results of his annual physical. "Nathan, your results are generally good except for your triglycerides and cholesterol. They are off the chart. For someone who is so conscious of how to stay healthy, you have ignored everything we know about elevated lipids."

CASE SCENARIO 5b
·         "Listen, doc," Nathan says, smiling. "Everything else looks good, right? No one ever died from high cholesterol. I wouldn't worry about it."
·         Dr. Wechsler hands Nathan a brochure that appears to discuss the significance of elevated lipids and says, "Read this, Nathan. Perhaps you will gain an appropriate perspective from it. Triglycerides are a form of fat in the bloodstream. People with high triglycerides often have high cholesterol, which puts you at risk for make some major changes in your diet and perhaps take a lipid-lowering agent. You should remove red meat and foods high in sugar from your diet."

CASE SCENARIO 5c
·         Nathan looks at the doctor with dismay, thinking about how much he loves Monday’s steak night at his favorite restaurant.
·         The doctor provides Nathan with a diet sheet and a prescription for a lipid-lowering agent after discussing the changes that need to be made.
·         Nathan thanks the doctor and leaves the office. When he gets into his car, Nathan throws the diet sheet in the back seat, saying to himself, “I got one life; I’m not giving up steak night.”

Mo Med. 2011 Nov-Dec;108(6):439-42.
·         A variety of authors have suggested that children and adolescents are at risk for serious adverse health outcomes because of a lack of compliance with medication regimens. A lack of compliance includes taking less or more medication than prescribed, and taking medication at the wrong times.
·         One study that examined the medication compliance of 81 students who were 10 years of age or older, and were enrolled in a school-based health center, determined that only 45 students (56%) filled the prescription given to them by the doctor.
·         Of those students who filled the prescription, 76% reported that they always took the medication on time, 22% reported forgetting to take the medication some of the time and 2% reported never taking the medication.

Culig J,  et al. Arch Pharm Res. 2011 Jul;34(7):1143-52. .
·         The great majority of study subjects reported forgetfulness as the main reason for skipping drug doses.
·         There was no difference in medication compliance between the general patient population and patients receiving antihypertensive therapy and there was no correlation between medication compliance and age.

Hacihasanoğlu R,  et al. J Clin Nurs. 2011 Mar;20(5-6):692-705.
·         Healthy lifestyle behaviours and perception of self-efficacy regarding medication adherence showed improvement after education sessions.
·         Systolic and diastolic blood pressures of subjects showed a significant decrease in those who got education compared with those of the control group
·         Patient education medication adherence alone and in combination with healthy lifestyle behaviour teaching is an effective tool for blood pressure reduction in the hypertensive population in primary health care settings.

Suzuki T et al.Yakugaku Zasshi. 2011 Jan;131(1):129-38.
·         The inhaled corticosteroids adherence of the patients with a family asthma medical history were significantly higher (p=0.034) than those without this medical history.
·         The ratio of the asthma-related emergency department visits of the patients with a family asthma medical history were significantly lower (p=0.043) than those without this medical history.
·         A significant correlation between the mean patients' adherence and the asthma symptom severity at the end of surveillance was found (p=0.010),

Chen HF et al. Epilepsy Behav. 2010 Sep;19(1):43-9.
·         Logistic regression analysis indicated that comorbid chronic disease, self-driving, seizure after a missed dose, and self-efficacy were significantly associated with medication compliance.
·         These data suggest that health care providers of patients with epilepsy pay more attention to treatment of comorbid chronic diseases, the safety issues of self-driving, seizures occurring after missed doses, and awareness of self-efficacy.

Köberlein J et al. Asian Pac J Allergy Immunol. 2013 Jun;31(2):148-56
·         There was a compliance rate of 79.6% with the administration of sublingual immunotherapy. Factors associated with compliance were severe nasal, eye and airways symptoms, and strong impairment in social and work life.
·         Compliance with the intake of H1-antihistamines was 98%.
·         Patients with a concomitant disease, especially with a bronchialasthma or a psychiatric disorder had higher odds for being non-compliant.

Aleem AJ et al. Surg Orthop Adv. 2011 Fall;20(3):182-7.
·         Patient followup compliance decreased over time [6 months (82%), 1 year (78%), 2 year (37%)].
·         Attendance at 6-month followup was found to be a significant positive predictor for 1-year followup. Using a multivariate model,
·         obesity was found to be a negative predictor for 2-year followup,
·         compliance with 6-month and 1-year followup was found to be a positive predictor for 2-year followup. The data shows that current patient-dependent followup protocols are ineffective beyond one year, with only 37% of patients returning for their 2-year visit. Inclusion of a 6-month visit may improve 1-year followup, but 2-year followup remained low.

Oikonomidou E, et al. BMC Gastroenterol. 2011 Feb 14;11:11.
·         Patients with dyspepsia in rural Greece tend to avoid upper gastrointestinal endoscopy
·         Causes of patients' refusal: their beliefs towards endoscopy and their personal capability to cope with it.

Can J Cardiovasc Nurs. 2009;19(1):7-12.
·         Despite the availability of effective treatment, more than half of patients treated for hypertension drop out of care entirely within a year of diagnosis.
·         Fifty per cent of patients who remain under medical supervision take only 80% of their prescribed medications.
·         75% of patients with a diagnosis of hypertension do not achieve optimum blood pressure control due to poor adherence to anti-hypertensive treatment.