Agenda of Meeting with PNU Students prepared by Prof Omar Hasan Kasule MB ChB (MUK), MPH (Harvard), DrPH (Harvard).
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Time |
Sunday Jan 5, 2025 |
Monday Dec 6, 2025 |
Tuesday Dec 7, 2025 |
Wednesday Dec 8, 2025 |
Thursday Dec 9, 2025 |
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7.00pm – 7.55pm
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Group 1 |
Group 4 |
Group 7 |
Group 10 |
Group 13 |
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8.00pm – 8.55pm
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Group 2 |
Group 5 |
Group 8 |
Group 11 |
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9.00pm – 9.55pm
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Group 3 |
Group 6 |
Group 9 |
Group 12 |
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AGENDA
- Know one another: self-introductions – 5 minutes.
- The way forward – 5 minutes.
- Presentation of the proposed research program -5 minutes.
- Q&A and open discussion – 30 minutes.
WAY FORWARD
- Vision: publish at least 2 papers; the first a review within 6 months and the second based on laboratory or data analysis within 1-3 years.
- First step: We shall start by brainstorming about the assigned topic, then the group will review the literature to narrow down the topic and develop keywords.
- Second step: Systematic literature review within the group and a 1-hour presentation to Prof Omar once a week or once every two weeks.
- Third step: familiarization with available laboratory equipment and procedures to prepare one or more research proposals from each group. Faculty will be appointed as supervisors or principal investigators. Students will be co-authors.
- Some of the research will be new and innovative. Some of it will be attempts at validating research carried out outside the Kingdom.
RESEARCH PROGRAM ON MECHANISMS AND FACTORS MODULATING
HEMATOPIETIC STEM CELL (HSC) AGEING-1
- The purpose of this program is to contribute to the HEVOLUTION Foundation's research on aging by focusing on the biology of ageing in HSCs.
- The program accepts research proposals on the mechanisms of HSC aging, its cell-intrinsic and cell-extrinsic causes, and in vitro and in vivo interventions that delay, reverse, or rejuvenate the aging cells.
- HSCs' aging is associated with malignancies and co-morbidities because of their vital role in the homeostasis of the cardiovascular, respiratory, and other body systems.
- HSCs are selected as a model of cell aging because of the ease of obtaining them from peripheral circulation and their short life span.
- The findings from HSCs will be used in further research on other tissues, human and animal.
RESEARCH PROGRAM ON MECHANISMS AND FACTORS MODULATING
HEMATOPOIETIC STEM CELL (HSC) AGEING-2
Four types of research proposals will be accepted:
- Description of manifestations of HSC aging: decreased self-renewal ability, myeloid-biased differentiation, impaired homing, and other abnormalities related to hematopoietic repair function
- Identification of cell-intrinsic (e.g., DNA damage, Epigenetics, autophagy, proteostasis, metabolic changes, inflammation, etc.) and cell-extrinsic causes /modulators of HSC aging in the extracellular microenvironment
- Description of mechanisms of HSC aging at the cellular, molecular, and genetic levels
- Proposing and testing interventions that lead to HSC rejuvenation (proved by evidence) with the eventual vision of translational research that will lead to therapeutic interventions.
INITIAL REVIEW ARTICLES
- Takeshi Fujino , Shuhei Asada , Susumu Goyama , Toshio Kitamura. Mechanisms involved in hematopoietic stem cell aging. Cell Mol Life Sci. 2022 Aug 8;79(9):473.
- Eva Mejia-Ramirez , Maria Carolina Florian. Understanding intrinsic hematopoietic stem cell aging.. Haematologica. 2020 Jan;105(1):22-37.
- Soheila Montazersaheb, Ali Ehsani, Ezzatollah Fathi, Raheleh Farahzadi. Cellular and
Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical
Prospect. Oxid
Med Cell Longev. 2022 Apr 1;2022:2713483.
- Martin Wahlestedt, David Bryder. The slippery slope of hematopoietic stem cell aging. Exp Hematol. 2017 Dec;56:1-6.
- Els Mansell, Dawn S Lin, Stephen J Loughran, Michael D Milsom, Jennifer J Trowbridge. New Insight into the Causes, Consequences and Correction of Hematopoietic Stem Cell Ageing. Exp Hematol. 2023 Jul 9;S0301-472X(23)01614-4